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Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

Upon release from necrotic cells, HMGB1 triggers neuro-inflammation through interactions with TLR-2, TLR-4, TLR-9, and RAGE

Martinez-Valbuena et al., 2019), and decreased insulin signaling in the brain can inhibit phosphatidylinositol 3-kinase/Akt and activate GSK-3 (Ma et al., 2015)